hrp0082s5.2 | Novel Insights into Hypoadrenalism | ESPE2014

Adrenarche: Coming of Age in the Era of Genomics and Metabolomics

Rainey William

The human adrenal cortex produces a wide range of steroids that includes aldosterone, cortisol and a variety of 19 carbon (C19) steroids; the most studied being DHEA. In humans, adrenarche is the endocrine developmental process manifested by an increased adrenal output of DHEA. This phenomenon corresponds with the expansion of the zona reticularis of the adrenal gland. However, the physiological mechanisms that trigger adrenarche remain elusive. Our research focuses...